A Porcine Ex Vivo Lung Perfusion Model To Investigate Bacterial Pathogenesis
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چکیده
منابع مشابه
A porcine ex vivo lung perfusion model with maximal argon exposure to attenuate ischemia-reperfusion injury
Argon (Ar) is a noble gas with known organoprotective effects in rodents and in vitro models. In a previous study we failed to find a postconditioning effect of Ar during ex vivo lung perfusion (EVLP) on warm-ischemic injury in a porcine model. In this study, we further investigated a prolonged exposure to Ar to decrease cold ischemia-reperfusion injury after lung transplantation in a porcine m...
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OBJECTIVE To evaluate the use of ex vivo lung perfusion (EVLP) clinically to prepare donor lungs for transplantation. METHODS A prospective study involving EVLP for the reconditioning of extended-criteria donor lungs, the criteria for which include aspects such as a PaO2/FiO2 ratio < 300 mmHg. Between February of 2013 and February of 2014, the lungs of five donors were submitted to EVLP for u...
متن کاملTowards a better understanding of ex vivo lung perfusion.
Ex vivo lung perfusion (EVLP) is probably the most promising technique currently available to substantially increase the number of acceptable donor lungs and to improve the outcome after lung transplantation. Several ongoing prospective single and multicentre trials are currently investigating the potential and the individual advantages of different platforms available for EVLP. So far, a numbe...
متن کاملComparison of lung preservation solutions in human lungs using an ex vivo lung perfusion experimental model
OBJECTIVE Experimental studies on lung preservation have always been performed using animal models. We present ex vivo lung perfusion as a new model for the study of lung preservation. Using human lungs instead of animal models may bring the results of experimental studies closer to what could be expected in clinical practice. METHOD Brain-dead donors whose lungs had been declined by transpla...
متن کاملLung flooding enables efficient lung sonography and tumour imaging in human ex vivo and porcine in vivo lung cancer model
BACKGROUND Sonography has become the imaging technique of choice for guiding intraoperative interventions in abdominal surgery. Due to artefacts from residual air content, however, videothoracoscopic and open intraoperative ultrasound-guided thermoablation of lung malignancies are impossible. Lung flooding is a new method that allows complete ultrasound imaging of lungs and their tumours. MET...
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ژورنال
عنوان ژورنال: mBio
سال: 2019
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.02802-19